Your browser doesn't support javascript.
loading
A shared disease-associated oligodendrocyte signature among multiple CNS pathologies.
Kenigsbuch, Mor; Bost, Pierre; Halevi, Shahar; Chang, Yuzhou; Chen, Shuo; Ma, Qin; Hajbi, Renana; Schwikowski, Benno; Bodenmiller, Bernd; Fu, Hongjun; Schwartz, Michal; Amit, Ido.
Afiliação
  • Kenigsbuch M; Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel.
  • Bost P; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
  • Halevi S; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
  • Chang Y; Systems Biology Group, Center for Bioinformatics, Biostatistics and Integrative Biology, Institut Pasteur CNRS, Paris, France.
  • Chen S; Sorbonne Université, Complexité du vivant, Paris, France.
  • Ma Q; University of Zurich, Zurich, Switzerland.
  • Hajbi R; Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel.
  • Schwikowski B; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
  • Bodenmiller B; Department of Biomedical Informatics, College of Medicine, Ohio State University, Columbus, OH, USA.
  • Fu H; Biomedical Sciences Graduate Program, Ohio State University, Columbus, OH, USA.
  • Schwartz M; Biomedical Sciences Graduate Program, Ohio State University, Columbus, OH, USA.
  • Amit I; Department of Neuroscience, College of Medicine, Ohio State University, Columbus, OH, USA.
Nat Neurosci ; 25(7): 876-886, 2022 07.
Article em En | MEDLINE | ID: mdl-35760863
Alzheimer's disease (AD) is a complex neurodegenerative disease, perturbing neuronal and non-neuronal cell populations. In this study, using single-cell transcriptomics, we mapped all non-immune, non-neuronal cell populations in wild-type and AD model (5xFAD) mouse brains. We identified an oligodendrocyte state that increased in association with brain pathology, which we termed disease-associated oligodendrocytes (DOLs). In a murine model of amyloidosis, DOLs appear long after plaque accumulation, and amyloid-beta (Aß) alone was not sufficient to induce the DOL signature in vitro. DOLs could be identified in a mouse model of tauopathy and in other murine neurodegenerative and autoimmune inflammatory conditions, suggesting a common response to severe pathological conditions. Using quantitative spatial analysis of mouse and postmortem human brain tissues, we found that oligodendrocytes expressing a key DOL marker (SERPINA3N/SERPINA3 accordingly) are present in the cortex in areas of brain damage and are enriched near Aß plaques. In postmortem human brain tissue, the expression level of this marker correlated with cognitive decline. Altogether, this study uncovers a shared signature of oligodendrocytes in central nervous system pathologies.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Neurodegenerativas / Doença de Alzheimer Tipo de estudo: Risk_factors_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Neurodegenerativas / Doença de Alzheimer Tipo de estudo: Risk_factors_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article