Kinome profiling of cholangiocarcinoma organoids reveals potential druggable targets that hold promise for treatment stratification.

Lieshout, Ruby; Faria, Alessandra V S; Peppelenbosch, Maikel P; van der Laan, Luc J W; Verstegen, Monique M A; Fuhler, Gwenny M

Lieshout, Ruby; Faria, Alessandra V S; Peppelenbosch, Maikel P; van der Laan, Luc J W; Verstegen, Monique M A; Fuhler, Gwenny M.

Afiliação

Lieshout R; Erasmus MC Transplant Institute, Department of Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands.
Faria AVS; Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Peppelenbosch MP; Department of Biochemistry and Tissue Biology, University of Campinas, UNICAMP, Campinas, Brazil.
van der Laan LJW; Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Verstegen MMA; Erasmus MC Transplant Institute, Department of Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands.
Fuhler GM; Erasmus MC Transplant Institute, Department of Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands.

Mol Med ; 28(1): 74, 2022 06 28.

Article em En | MEDLINE | ID: mdl-35764936

Assuntos

Neoplasias dos Ductos Biliares; Colangiocarcinoma; Neoplasias dos Ductos Biliares/tratamento farmacológico; Ductos Biliares Intra-Hepáticos; Colangiocarcinoma/tratamento farmacológico; Humanos; Organoides; Inibidores de Proteínas Quinases/farmacologia; Inibidores de Proteínas Quinases/uso terapêutico

Palavras-chave

Cholangiocarcinoma; Drug screening; Kinome profiling

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias dos Ductos Biliares / Colangiocarcinoma Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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