Recurrent VGLL3 fusions define a distinctive subset of spindle cell rhabdomyosarcoma with an indolent clinical course and striking predilection for the head and neck.

Agaimy, Abbas; Dermawan, Josephine K; Leong, Iona; Stoehr, Robert; Swanson, David; Weinreb, Ilan; Zhang, Lingxin; Antonescu, Cristina R; Dickson, Brendan C

Agaimy, Abbas; Dermawan, Josephine K; Leong, Iona; Stoehr, Robert; Swanson, David; Weinreb, Ilan; Zhang, Lingxin; Antonescu, Cristina R; Dickson, Brendan C.

Afiliação

Agaimy A; Institute of Pathology, Erlangen University Hospital, Comprehensive Cancer Center, European Metropolitan Area Erlangen-Nuremberg, Friedrich Alexander University of Erlangen-Nuremberg, Erlangen, Germany.
Dermawan JK; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Leong I; Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada.
Stoehr R; Department of Pathology & Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada.
Swanson D; Department of Pathobiology and Laboratory Medicine, University of Toronto, Toronto, Ontario, Canada.
Weinreb I; Institute of Pathology, Erlangen University Hospital, Comprehensive Cancer Center, European Metropolitan Area Erlangen-Nuremberg, Friedrich Alexander University of Erlangen-Nuremberg, Erlangen, Germany.
Zhang L; Department of Pathology & Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada.
Antonescu CR; Department of Pathobiology and Laboratory Medicine, University of Toronto, Toronto, Ontario, Canada.
Dickson BC; Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada.

Genes Chromosomes Cancer ; 61(12): 701-709, 2022 12.

Article em En | MEDLINE | ID: mdl-35766997

Assuntos

Rabdomiossarcoma; Neoplasias de Tecidos Moles; Fatores de Transcrição; Actinas; Adulto; Idoso; Biomarcadores Tumorais/genética; Biomarcadores Tumorais/metabolismo; Proteínas de Ligação a DNA; Desmina; Feminino; Humanos; Masculino; Pessoa de Meia-Idade; Miogenina/genética; Rabdomiossarcoma/química; Rabdomiossarcoma/patologia; Neoplasias de Tecidos Moles/patologia; Fatores de Transcrição/genética

Palavras-chave

EP300; PPARGC1A; TCF12; VGLL3; gene fusion; head and neck; sarcoma; spindle cell rhabdomyosarcoma

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Rabdomiossarcoma / Neoplasias de Tecidos Moles / Fatores de Transcrição Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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