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Delivery of therapeutic carbon monoxide by gas-entrapping materials.
Byrne, James D; Gallo, David; Boyce, Hannah; Becker, Sarah L; Kezar, Kristi M; Cotoia, Alicia T; Feig, Vivian R; Lopes, Aaron; Csizmadia, Eva; Longhi, Maria Serena; Lee, Jung Seung; Kim, Hyunjoon; Wentworth, Adam J; Shankar, Sidharth; Lee, Ghee Rye; Bi, Jianling; Witt, Emily; Ishida, Keiko; Hayward, Alison; Kuosmanen, Johannes L P; Jenkins, Josh; Wainer, Jacob; Aragon, Aya; Wong, Kaitlyn; Steiger, Christoph; Jeck, William R; Bosch, Dustin E; Coleman, Mitchell C; Spitz, Douglas R; Tift, Michael; Langer, Robert; Otterbein, Leo E; Traverso, Giovanni.
Afiliação
  • Byrne JD; Division of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Gallo D; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Boyce H; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
  • Becker SL; Harvard Radiation Oncology Residency Program, Boston, MA 02114, USA.
  • Kezar KM; Department of Radiation Oncology, University of Iowa, Iowa City, IA 52242, USA.
  • Cotoia AT; Department of Biomedical Engineering, University of Iowa, Iowa City, IA 52240, USA.
  • Feig VR; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA 52242, USA.
  • Lopes A; Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Csizmadia E; Division of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Longhi MS; Division of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Lee JS; Department of Biology and Marine Biology, University of North Carolina Wilmington, Wilmington, NC 28403, USA.
  • Kim H; Department of Biology and Marine Biology, University of North Carolina Wilmington, Wilmington, NC 28403, USA.
  • Wentworth AJ; Division of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Shankar S; Division of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Lee GR; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Bi J; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
  • Witt E; Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Ishida K; Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Hayward A; Division of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Kuosmanen JLP; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Jenkins J; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
  • Wainer J; Department of Intelligent Precision Healthcare Convergence, SKKU Institute of Convergence, Sungkyunkwan University, Suwon 16419, South Korea.
  • Aragon A; Division of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Wong K; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Steiger C; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
  • Jeck WR; Division of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Bosch DE; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Coleman MC; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
  • Spitz DR; Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Tift M; Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Langer R; Department of Radiation Oncology, University of Iowa, Iowa City, IA 52242, USA.
  • Otterbein LE; Department of Radiation Oncology, University of Iowa, Iowa City, IA 52242, USA.
  • Traverso G; Division of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Sci Transl Med ; 14(651): eabl4135, 2022 06 29.
Article em En | MEDLINE | ID: mdl-35767653
ABSTRACT
Carbon monoxide (CO) has long been considered a toxic gas but is now a recognized bioactive gasotransmitter with potent immunomodulatory effects. Although inhaled CO is currently under investigation for use in patients with lung disease, this mode of administration can present clinical challenges. The capacity to deliver CO directly and safely to the gastrointestinal (GI) tract could transform the management of diseases affecting the GI mucosa such as inflammatory bowel disease or radiation injury. To address this unmet need, inspired by molecular gastronomy techniques, we have developed a family of gas-entrapping materials (GEMs) for delivery of CO to the GI tract. We show highly tunable and potent delivery of CO, achieving clinically relevant CO concentrations in vivo in rodent and swine models. To support the potential range of applications of foam GEMs, we evaluated the system in three distinct disease models. We show that a GEM containing CO dose-dependently reduced acetaminophen-induced hepatocellular injury, dampened colitis-associated inflammation and oxidative tissue injury, and mitigated radiation-induced gut epithelial damage in rodents. Collectively, foam GEMs have potential paradigm-shifting implications for the safe therapeutic use of CO across a range of indications.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Inflamatórias Intestinais / Colite Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Inflamatórias Intestinais / Colite Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article