Antibacterial peptide CyclomarinA creates toxicity by deregulating the Mycobacterium tuberculosis ClpC1-ClpP1P2 protease.

Taylor, Gabrielle; Frommherz, Yannick; Katikaridis, Panagiotis; Layer, Dominik; Sinning, Irmgard; Carroni, Marta; Weber-Ban, Eilika; Mogk, Axel

Taylor, Gabrielle; Frommherz, Yannick; Katikaridis, Panagiotis; Layer, Dominik; Sinning, Irmgard; Carroni, Marta; Weber-Ban, Eilika; Mogk, Axel.

Afiliação

Taylor G; ETH Zurich, Institute of Molecular Biology and Biophysics, Zurich, Switzerland.
Frommherz Y; Center for Molecular Biology of the University of Heidelberg (ZMBH), DKFZ-ZMBH Alliance, Heidelberg, Germany; Division of Chaperones and Proteases, Division of Chaperones and Proteases, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.
Katikaridis P; Center for Molecular Biology of the University of Heidelberg (ZMBH), DKFZ-ZMBH Alliance, Heidelberg, Germany; Division of Chaperones and Proteases, Division of Chaperones and Proteases, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.
Layer D; Heidelberg University Biochemistry Center (BZH), Heidelberg, Germany.
Sinning I; Heidelberg University Biochemistry Center (BZH), Heidelberg, Germany.
Carroni M; Swedish Cryo-EM Facility, Science for Life Laboratory Stockholm University, Solna, Sweden.
Weber-Ban E; ETH Zurich, Institute of Molecular Biology and Biophysics, Zurich, Switzerland. Electronic address: eilika@mol.biol.ethz.ch.
Mogk A; Center for Molecular Biology of the University of Heidelberg (ZMBH), DKFZ-ZMBH Alliance, Heidelberg, Germany; Division of Chaperones and Proteases, Division of Chaperones and Proteases, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany. Electronic address: a.mogk@zmbh.uni-heidelberg.de.

J Biol Chem ; 298(8): 102202, 2022 08.

Article em En | MEDLINE | ID: mdl-35768046

Assuntos

Antibacterianos/farmacologia; Proteínas de Bactérias/metabolismo; Endopeptidase Clp/metabolismo; Proteínas de Choque Térmico/metabolismo; Mycobacterium tuberculosis; Oligopeptídeos/farmacologia; Proteínas de Bactérias/química; Endopeptidase Clp/química; Endopeptidases/metabolismo; Escherichia coli/metabolismo; Proteínas de Choque Térmico/química; Mycobacterium tuberculosis/enzimologia; Mycobacterium tuberculosis/metabolismo; Peptídeo Hidrolases/metabolismo; Peptídeos/metabolismo

Palavras-chave

ATPase Associated with diverse cellular Activities; ClpC; CyclomarinA; antibiotic action; protease; protein degradation; proteostasis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oligopeptídeos / Proteínas de Bactérias / Endopeptidase Clp / Proteínas de Choque Térmico / Antibacterianos / Mycobacterium tuberculosis Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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