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Traumatic brain injury and post-traumatic stress disorder are not associated with Alzheimer's disease pathology measured with biomarkers.
Weiner, Michael W; Harvey, Danielle; Landau, Susan M; Veitch, Dallas P; Neylan, Thomas C; Grafman, Jordan H; Aisen, Paul S; Petersen, Ronald C; Jack, Clifford R; Tosun, Duygu; Shaw, Leslie M; Trojanowski, John Q; Saykin, Andrew J; Hayes, Jacqueline; De Carli, Charles.
Afiliação
  • Weiner MW; Department of Veterans Affairs Medical Center, Center for Imaging of Neurodegenerative Diseases, San Francisco, California, USA.
  • Harvey D; Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.
  • Landau SM; Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
  • Veitch DP; Department of Psychiatry, University of California, San Francisco, San Francisco, California, USA.
  • Neylan TC; Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
  • Grafman JH; Division of Biostatistics, Department of Public Health Sciences, University of California, Davis, Davis, California, USA.
  • Aisen PS; Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, California, USA.
  • Petersen RC; Department of Veterans Affairs Medical Center, Center for Imaging of Neurodegenerative Diseases, San Francisco, California, USA.
  • Jack CR; Northern California Institute for Research and Education (NCIRE), Department of Veterans Affairs Medical Center, San Francisco, California, USA.
  • Tosun D; Department of Psychiatry, University of California, San Francisco, San Francisco, California, USA.
  • Shaw LM; Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
  • Trojanowski JQ; Shirley Ryan AbilityLab, Northwestern University School of Medicine, Chicago, Illinois, USA.
  • Saykin AJ; Alzheimer's Therapeutic Research Institute, University of Southern California, San Diego, La Jolla, California, USA.
  • Hayes J; Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
  • De Carli C; Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Alzheimers Dement ; 2022 Jun 29.
Article em En | MEDLINE | ID: mdl-35768339
ABSTRACT

INTRODUCTION:

Epidemiological studies report an association between traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) and clinically diagnosed Alzheimer's disease (AD). We examined the association between TBI/PTSD and biomarker-defined AD.

METHODS:

We identified 289 non-demented veterans with TBI and/or PTSD and controls who underwent clinical evaluation, cerebrospinal fluid (CSF) collection, magnetic resonance imaging (MRI), amyloid beta (Aß) and tau positron emission tomography, and apolipoprotein E testing. Participants were followed for up to 5.2 years.

RESULTS:

Exposure groups (TBI, PTSD, and TBI + PTSD) had higher prevalence of mild cognitive impairment (MCI P < .0001) and worse Mini-Mental State Examination scores (PTSD P = .008; TBI & PTSD P = .009) than controls. There were no significant differences in other cognitive scores, MRI volumes, Aß or tau accumulation, or in most longitudinal measures.

DISCUSSION:

TBI and/or PTSD were not associated with elevated AD biomarkers. The poorer cognitive status of exposed veterans may be due to other comorbid pathologies.
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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Ano de publicação: 2022 Tipo de documento: Article