Excretion of cobalamin and haptocorrin in the meconium of cystic fibrosis, premature, and control neonates.
Am J Clin Nutr
; 45(5): 981-7, 1987 May.
Article
em En
| MEDLINE
| ID: mdl-3578099
ABSTRACT
Excretion of haptocorrin (R binder), cobalamin, and other corrinoids was studied in meconium from cystic fibrosis (n = 4), premature (n = 3), and control neonates (n = 13). Corrinoids content was 1.67 +/- 0.92 pmol/mg protein in meconium of cystic fibrosis (CF) neonates but only 0.33 +/- 0.37 and 0.48 +/- 0.47 pmol/mg protein, respectively, in that of prematures and controls. Considering its molecular mass (110,100 +/- 10,100) and its mean isoelectric point (3.67 +/- 0.20), haptocorrin remained undergraded in the meconium of CF neonates whereas it was partially degraded in the meconium of prematures and in most of the meconium from controls. Sequestration of cobalamin by undergraded haptocorrin can explain its increased excretion in CF meconium. Cobalamin-binding capacity of haptocorrin was 22.13 +/- 15.50 pmol/mg protein in CF meconium and about 400-fold lower in meconium of prematures and controls. This may correspond to a fetal intestinal hypersecretion in cases of CF.
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Base de dados:
MEDLINE
Assunto principal:
Vitamina B 12
/
Recém-Nascido Prematuro
/
Transcobalaminas
/
Fibrose Cística
/
Mecônio
Limite:
Humans
/
Newborn
Idioma:
En
Ano de publicação:
1987
Tipo de documento:
Article