3D, three-dimensional; ACC, adrenocortical carcinoma; AUC, area under the curve; BLCA, bladder urothelial carcinoma; BRCA, breast invasive carcinoma; Biomarker; CAF, cancer-associated fibroblasts; CCLE, cancer cell line encyclopedia; CESC, cervical squamous cell carcinoma and endocervical adenocarcinoma; CHOL, cholangiocarcinoma; COAD, colon adenocarcinoma; DEGs, differentially expressed genes; DFS, disease free survival; DLBC, lymphoid neoplasm diffuse large B-cell lymphoma; DSS, disease specific survival; Diagnosis; ER, endoplasmic reticulum; ESCA, esophageal carcinoma; GBM, glioblastoma multiforme; GO, Gene Ontology; GSEA, Gene Set Enrichment Analysis; GTEx, genotype-tissue expression; HNSC, head and neck squamous cell carcinoma; HR, hazard ratio; ICIs, immune checkpoint inhibitors; Immuno-oncology; KEGG, Kyoto encyclopedia of genes and genomes; KICH, kidney chromophobe; KIRC, kidney renal clear cell carcinoma; KIRP, kidney renal papillary cell carcinoma; LAML, acute myeloid leukemia; LGG, brain lower grade glioma; LIHC, liver hepatocellular carcinoma; LUAD, lung adenocarcinoma; LUSC, lung squamous cell carcinoma; MDSC, myeloid-derived suppressor cells; MESO, mesothelioma; MSI, microsatellite instability; OS, overall survival; OV, ovarian serous cystadenocarcinoma; PAAD, pancreatic adenocarcinoma; PCPG, pheochromocytoma and paraganglioma; PFS, progression free survival; PPI, protein­protein interaction; PRAD, prostate adenocarcinoma; Pan-cancer; Prognosis; READ, rectum adenocarcinoma; ROC, receiver operating characteristic; SARC, sarcoma; SHCBP1; SHCBP1, Shc SH2-domain binding protein 1; SKCM, skin cutaneous melanoma; STAD, stomach adenocarcinoma; TAM, tumor-associated macrophages; TCGA, the cancer genome atlas; TGCT, testicular germ cell tumors; THCA, thyroid carcinoma; THPA, the human protein atlas; THYM, thymoma; TIME, tumor immune microenvironment; TIMER 2.0, tumor immune estimation resource, version 2; TMB, tumor mutational burden; UCEC, uterine corpus endometrial carcinoma; UCS, uterine carcinosarcoma; UVM, uveal melanoma