Anti-neuroinflammatory sesquiterpenoids from Chloranthus henryi.
Nat Prod Res
; 37(6): 882-890, 2023 Mar.
Article
em En
| MEDLINE
| ID: mdl-35797089
ABSTRACT
Hupelactones A (1) and B (2), two new eudesmanolide-type enantiomers of the corresponding compounds, along with four mono- (3-6) and nine dimeric- (7-15) known sesquiterpenoids were isolated from the whole plant of Chloranthus henryi var. hupehensis (syn. C. henryi). The new structures including the absolute configurations were determined by comparison with previously reported enantiomers, extensive spectroscopic methods in combination with electronic circular dichroism (ECD) calculations. All the isolates were evaluated for their inhibitory activities against the lipopolysaccharide (LPS)-induced nitric oxide (NO) production in murine BV-2 microglial cells. Among them, the dimeric lindenane sesquiterpenoids shizukaols F (8) and G (11) exhibited the most potent activities, with IC50 values of 2.65 and 4.60 µM, respectively.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sesquiterpenos
/
Magnoliopsida
Limite:
Animals
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article