Transcription factor hijacking in the name of tolerance.
Cell
; 185(14): 2398-2400, 2022 07 07.
Article
em En
| MEDLINE
| ID: mdl-35803243
ABSTRACT
Thymus epithelial cells (TECs) express antigens from peripheral tissues to select against autoreactive T cells and thus prevent autoimmunity. Michelsen et al. now show that molecularly defined clusters of thymic epithelial cells express and depend on skin-, lung-, liver- or intestinal-cell transcription factors that are co-opted by the thymus to drive ectopic gene expression.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Tolerância Imunológica
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article