Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications.
Cell
; 185(14): 2401-2421, 2022 07 07.
Article
em En
| MEDLINE
| ID: mdl-35803244
ABSTRACT
Ferroptosis, a form of cell death driven by iron-dependent lipid peroxidation, was identified as a distinct phenomenon and named a decade ago. Ferroptosis has been implicated in a broad set of biological contexts, from development to aging, immunity, and cancer. This review describes key regulators of this form of cell death within a framework of metabolism, ROS biology, and iron biology. Key concepts and major unanswered questions in the ferroptosis field are highlighted. The next decade promises to yield further breakthroughs in the mechanisms governing ferroptosis and additional ways of harnessing ferroptosis for therapeutic benefit.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ferroptose
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article