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Gal-3BP in Viral Infections: An Emerging Role in Severe Acute Respiratory Syndrome Coronavirus 2.
Gallo, Valentina; Arienzo, Alyexandra; Iacobelli, Stefano; Iacobelli, Valentina; Antonini, Giovanni.
Afiliação
  • Gallo V; Department of Sciences, Roma Tre University, Viale G. Marconi, 00146 Rome, Italy.
  • Arienzo A; Biostructures and Biosystems National Institute (INBB), Viale delle Medaglie d'Oro, 00136 Rome, Italy.
  • Iacobelli S; MediaPharma Srl, Via Colle dell'Ara, 66013 Chieti, Italy.
  • Iacobelli V; MediaPharma Srl, Via Colle dell'Ara, 66013 Chieti, Italy.
  • Antonini G; Department of Sciences, Roma Tre University, Viale G. Marconi, 00146 Rome, Italy.
Int J Mol Sci ; 23(13)2022 Jun 30.
Article em En | MEDLINE | ID: mdl-35806317
Galectin-3 binding protein (Gal-3BP) is a multifunctional glycoprotein involved in cell-cell and cell-matrix interactions known to be upregulated in cancer and various viral infections, including HIV-1, HCV, and SARS-CoV-2, with a key role in regulating the antiviral immune response. Studies have identified a direct correlation between circulating levels of Gal-3BP and the severity of disease and/or disease progression for some viral infections, including SARS-CoV-2, suggesting a role of Gal-3BP in these processes. Due to Gal-3BP's complex biology, the molecular mechanisms underlying its role in viral diseases have been only partially clarified. Gal-3BP induces the expression of interferons (IFNs) and proinflammatory cytokines, including interleukin-6 (IL-6), mainly interacting with galectin-3, targeting the TNF receptor-associated factors (TRAF-6 and TRAF-3) complex, thus having a putative role in the modulation of TGF-ß signaling. In addition, an antiviral activity of Gal-3BP has been ascribed to a direct interaction of the protein with virus components. In this review, we explored the role of Gal-3BP in viral infections and the relationship between Gal-3BP upregulation and disease severity and progression, mainly focusing on SARS-CoV-2. Augmented knowledge of Gal-3BP's role in virus infections can be useful to evaluate its possible use as a prognostic biomarker and as a putative target to block or attenuate severe disease.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Viroses / COVID-19 Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Viroses / COVID-19 Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article