Multitier mechanics control stromal adaptations in the swelling lymph node.
Nat Immunol
; 23(8): 1246-1255, 2022 08.
Article
em En
| MEDLINE
| ID: mdl-35817845
ABSTRACT
Lymph nodes (LNs) comprise two main structural elements fibroblastic reticular cells that form dedicated niches for immune cell interaction and capsular fibroblasts that build a shell around the organ. Immunological challenge causes LNs to increase more than tenfold in size within a few days. Here, we characterized the biomechanics of LN swelling on the cellular and organ scale. We identified lymphocyte trapping by influx and proliferation as drivers of an outward pressure force, causing fibroblastic reticular cells of the T-zone (TRCs) and their associated conduits to stretch. After an initial phase of relaxation, TRCs sensed the resulting strain through cell matrix adhesions, which coordinated local growth and remodeling of the stromal network. While the expanded TRC network readopted its typical configuration, a massive fibrotic reaction of the organ capsule set in and countered further organ expansion. Thus, different fibroblast populations mechanically control LN swelling in a multitier fashion.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Células Estromais
/
Linfonodos
Limite:
Animals
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article