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Altered Maturation of the Skin Microbiome in Infants with Atopic Dermatitis.
Olesen, Caroline M; Clausen, Maja-Lisa; Agner, Tove; Asplund, Maria; Rasmussen, Linett; Yüksel, Yasemin T; Andersen, Paal S; Litman, Thomas; Hansen, Anders J; Barnes, Christopher J.
Afiliação
  • Olesen CM; Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Bispebjerg Bakke 23, DK-2400 Copenhagen NV, Denmark. cmo.dk@hotmail.com.
  • Clausen ML; Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Bispebjerg Bakke 23, DK-2400 Copenhagen NV, Denmark.
  • Agner T; Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Bispebjerg Bakke 23, DK-2400 Copenhagen NV, Denmark.
  • Asplund M; The Globe Institute, Faculty of Health, University of Copenhagen, Copenhagen, Denmark. anna.
  • Rasmussen L; The Globe Institute, Faculty of Health, University of Copenhagen, Copenhagen, Denmark.
  • Yüksel YT; Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Bispebjerg Bakke 23, DK-2400 Copenhagen NV, Denmark.
  • Andersen PS; Department of Bacteria, Parasites and Fungi, Statens Serum Institute, Copenhagen, Denmark.
  • Litman T; Department of Immunology and Microbiology, LEO Foundation Skin Immunology Research Center, University of Copenhagen, Copenhagen, Denmark.
  • Hansen AJ; The Globe Institute, Faculty of Health, University of Copenhagen, Copenhagen, Denmark.
  • Barnes CJ; The Globe Institute, Faculty of Health, University of Copenhagen, Copenhagen, Denmark.
Acta Derm Venereol ; 102: adv00817, 2022 Nov 21.
Article em En | MEDLINE | ID: mdl-35818733
ABSTRACT
The aim of this study was to investigate the early-life development of the skin microbiome in atopic dermatitis. Nineteen infants with atopic dermatitis and 19 healthy infants were evaluated 3 times, at 3 months intervals, within the first 30 months of life. Tape-strips were collected from volar forearms, cheeks, and eczema lesions, and the skin microbiome was assessed by 16S rRNA sequencing. Both the community structure and richness of the skin microbiome of infants with atopic dermatitis differed significantly from that of healthy infants, with greater richness in healthy infants. For infants with atopic dermatitis, the community composition was not dominated by Staphylococci. For healthy infants, community composition and richness correlated significantly with age, while such a pattern was not revealed in infants with atopic dermatitis. This suggests a slower maturation of the skin microbiome in atopic dermatitis, which precedes the staphylococcal predominance observed in older children and adults.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dermatite Atópica / Microbiota Tipo de estudo: Diagnostic_studies Limite: Adult / Child / Humans / Infant Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dermatite Atópica / Microbiota Tipo de estudo: Diagnostic_studies Limite: Adult / Child / Humans / Infant Idioma: En Ano de publicação: 2022 Tipo de documento: Article