Irinotecan dose reduction in metastatic colorectal cancer patients with homozygous <i>UGT1A1*28</i> polymorphism: a single-center case series.

Tsai, Hsiang-Lin; Chen, Po-Jung; Chen, Yen-Cheng; Li, Ching-Chun; Chang, Tsung-Kun; Su, Wei-Chih; Yin, Tzu-Chieh; Huang, Ching-Wen; Wang, Jaw-Yuan

Irinotecan dose reduction in metastatic colorectal cancer patients with homozygous UGT1A1*28 polymorphism: a single-center case series.

Tsai, Hsiang-Lin; Chen, Po-Jung; Chen, Yen-Cheng; Li, Ching-Chun; Chang, Tsung-Kun; Su, Wei-Chih; Yin, Tzu-Chieh; Huang, Ching-Wen; Wang, Jaw-Yuan.

Afiliação

Tsai HL; Division of Colorectal Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung.
Chen PJ; Department of Surgery, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung.
Chen YC; Division of Colorectal Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung.
Li CC; Division of Colorectal Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung.
Chang TK; Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung.
Su WC; Division of Colorectal Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung.
Yin TC; Division of Colorectal Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung.
Huang CW; Division of Colorectal Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung.
Wang JY; Division of Colorectal Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung.

J Int Med Res ; 50(7): 3000605221110697, 2022 Jul.

Article em En | MEDLINE | ID: mdl-35822291

Assuntos

Protocolos de Quimioterapia Combinada Antineoplásica; Neoplasias Colorretais; Glucuronosiltransferase; Protocolos de Quimioterapia Combinada Antineoplásica/administração & dosagem; Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos; Bevacizumab/administração & dosagem; Bevacizumab/efeitos adversos; Camptotecina/administração & dosagem; Camptotecina/efeitos adversos; Camptotecina/análogos & derivados; Cetuximab/administração & dosagem; Cetuximab/efeitos adversos; Neoplasias Colorretais/sangue; Neoplasias Colorretais/tratamento farmacológico; Neoplasias Colorretais/enzimologia; Neoplasias Colorretais/genética; Fluoruracila/administração & dosagem; Fluoruracila/efeitos adversos; Glucuronosiltransferase/genética; Glucuronosiltransferase/metabolismo; Humanos; Irinotecano/administração & dosagem; Irinotecano/efeitos adversos; Leucovorina/administração & dosagem; Leucovorina/efeitos adversos; Neutropenia/induzido quimicamente; Neutropenia/genética; Polimorfismo Genético

Palavras-chave

Case series; FOLFIRI; homozygous UGT1A1*28; irinotecan dose-reduction; metastatic colorectal cancer; poor metabolizer

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Protocolos de Quimioterapia Combinada Antineoplásica / Glucuronosiltransferase Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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