CDK7 Inhibition Synergizes with Topoisomerase I Inhibition in Small Cell Lung Cancer Cells by Inducing Ubiquitin-Mediated Proteolysis of RNA Polymerase II.

Sun, Yilun; Zhang, Yang; Schultz, Christopher W; Pommier, Yves; Thomas, Anish

Sun, Yilun; Zhang, Yang; Schultz, Christopher W; Pommier, Yves; Thomas, Anish.

Afiliação

Sun Y; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland.
Zhang Y; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland.
Schultz CW; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland.
Pommier Y; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland.
Thomas A; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland.

Mol Cancer Ther ; 21(9): 1430-1438, 2022 09 06.

Article em En | MEDLINE | ID: mdl-35830858

Assuntos

Antineoplásicos; Neoplasias Pulmonares; Carcinoma de Pequenas Células do Pulmão; Antineoplásicos/farmacologia; Linhagem Celular Tumoral; Quinases Ciclina-Dependentes/metabolismo; DNA Topoisomerases Tipo I/metabolismo; Humanos; Neoplasias Pulmonares/tratamento farmacológico; Inibidores de Proteínas Quinases/farmacologia; Proteólise; RNA Polimerase II/metabolismo; Carcinoma de Pequenas Células do Pulmão/tratamento farmacológico; Topotecan/farmacologia; Ubiquitina/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma de Pequenas Células do Pulmão / Neoplasias Pulmonares / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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