Detection and Quantification of ctDNA for Longitudinal Monitoring of Treatment in Non-Small Cell Lung Cancer Patients Using a Universal Mutant Detection Assay by Denaturing Capillary Electrophoresis.

Benesova, Lucie; Ptackova, Renata; Halkova, Tereza; Semyakina, Anastasiya; Svaton, Martin; Fiala, Ondrej; Pesek, Milos; Minarik, Marek

Benesova, Lucie; Ptackova, Renata; Halkova, Tereza; Semyakina, Anastasiya; Svaton, Martin; Fiala, Ondrej; Pesek, Milos; Minarik, Marek.

Afiliação

Benesova L; Center for Applied Genomics of Solid Tumors, Genomac Research Institute, Prague, Czechia.
Ptackova R; Center for Applied Genomics of Solid Tumors, Genomac Research Institute, Prague, Czechia.
Halkova T; Center for Applied Genomics of Solid Tumors, Genomac Research Institute, Prague, Czechia.
Semyakina A; Center for Applied Genomics of Solid Tumors, Genomac Research Institute, Prague, Czechia.
Svaton M; Department of Pneumology and Phtiseology, Faculty of Medicine and University Hospital in Pilsen, Charles University, Pilsen, Czechia.
Fiala O; Laboratory of Cancer Treatment and Tissue Regeneration, Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czechia.
Pesek M; Department of Oncology and Radiotherapeutics, Faculty of Medicine and University Hospital in Pilsen, Charles University, Pilsen, Czechia.
Minarik M; Department of Pneumology and Phtiseology, Faculty of Medicine and University Hospital in Pilsen, Charles University, Pilsen, Czechia.

Pathol Oncol Res ; 28: 1610308, 2022.

Article em En | MEDLINE | ID: mdl-35837614

Assuntos

Carcinoma Pulmonar de Células não Pequenas; DNA Tumoral Circulante; Neoplasias Pulmonares; Biomarcadores Tumorais/genética; Carcinoma Pulmonar de Células não Pequenas/genética; Carcinoma Pulmonar de Células não Pequenas/terapia; DNA Tumoral Circulante/genética; DNA de Neoplasias/genética; Eletroforese Capilar; Sequenciamento de Nucleotídeos em Larga Escala/métodos; Humanos; Neoplasias Pulmonares/tratamento farmacológico; Mutação/genética; Neoplasia Residual

Palavras-chave

KRAS mutations; NSCLC; TP53 mutations; capillary electrophoresis; ctDNA; liquid biopsy; minimal residual disease

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / DNA Tumoral Circulante / Neoplasias Pulmonares Tipo de estudo: Diagnostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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