NRF2/PGC-1&#945;-mediated mitochondrial biogenesis contributes to T-2 toxin-induced toxicity in human neuroblastoma SH-SY5Y cells.

Pang, Yue; Zhang, Li; Liu, Qiao; Peng, Hui; He, Jun; Jin, Hong; Su, Xueting; Zhao, Jun; Guo, Jiabin

NRF2/PGC-1α-mediated mitochondrial biogenesis contributes to T-2 toxin-induced toxicity in human neuroblastoma SH-SY5Y cells.

Pang, Yue; Zhang, Li; Liu, Qiao; Peng, Hui; He, Jun; Jin, Hong; Su, Xueting; Zhao, Jun; Guo, Jiabin.

Afiliação

Pang Y; Center for Disease Control and Prevention, Chinese PLA, 20 Dongdajie Street, Fengtai District, Beijing 100071, China; School of Public Health, China Medical University, 77 Puhe Road, Shenyang North New area, Shenyang 110122, China.
Zhang L; Center for Disease Control and Prevention, Chinese PLA, 20 Dongdajie Street, Fengtai District, Beijing 100071, China.
Liu Q; Center for Disease Control and Prevention, Chinese PLA, 20 Dongdajie Street, Fengtai District, Beijing 100071, China; School of Public Health, China Medical University, 77 Puhe Road, Shenyang North New area, Shenyang 110122, China.
Peng H; Center for Disease Control and Prevention, Chinese PLA, 20 Dongdajie Street, Fengtai District, Beijing 100071, China.
He J; Center for Disease Control and Prevention, Chinese PLA, 20 Dongdajie Street, Fengtai District, Beijing 100071, China.
Jin H; Center for Disease Control and Prevention, Chinese PLA, 20 Dongdajie Street, Fengtai District, Beijing 100071, China.
Su X; Center for Disease Control and Prevention, Chinese PLA, 20 Dongdajie Street, Fengtai District, Beijing 100071, China.
Zhao J; Center for Disease Control and Prevention, Chinese PLA, 20 Dongdajie Street, Fengtai District, Beijing 100071, China.
Guo J; Center for Disease Control and Prevention, Chinese PLA, 20 Dongdajie Street, Fengtai District, Beijing 100071, China; School of Public Health, China Medical University, 77 Puhe Road, Shenyang North New area, Shenyang 110122, China. Electronic address: gjb321@163.com.

Toxicol Appl Pharmacol ; 451: 116167, 2022 09 15.

Article em En | MEDLINE | ID: mdl-35842139

Assuntos

Neuroblastoma; Toxina T-2; Animais; DNA Mitocondrial/metabolismo; Humanos; Fator 2 Relacionado a NF-E2/genética; Fator 2 Relacionado a NF-E2/metabolismo; Biogênese de Organelas; Estresse Oxidativo; Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo/genética; Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo/metabolismo; Toxina T-2/toxicidade

Palavras-chave

Mitochondrial biogenesis; NRF2/PGC-1α; Neurotoxicity; Oxidative stress; T-2 toxin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Toxina T-2 / Neuroblastoma Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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