Factors influencing mosaicism: a retrospective analysis.
Reprod Biomed Online
; 45(3): 491-500, 2022 09.
Article
em En
| MEDLINE
| ID: mdl-35843780
ABSTRACT
RESEARCH QUESTION What factors affect the incidence of mosaic embryos resulting from assisted reproductive technology? DESIGN:
A retrospective analysis of data from preimplantation genetic testing for aneuploidies in 544 couples was conducted using data from an electronic medical record database.RESULTS:
Of 1910 embryos studied, 127 (6.6%) were mosaic. In multivariable logistic regression analysis, mosaicism incidence increased in embryos from IVF versus intracytoplasmic sperm injection (ICSI) (odds ratio [OR] 4.560, 95% confidence interval [CI] 2.800-7.424, P < 0.001), and in embryos from abnormal versus normal semen (OR 3.496, 95% CI 2.455-4.979, P < 0.001). Embryos tested using SurePlex 24Sure had lower mosaicism percentages than those tested using MALBAC-NGS and PicoPLEX GenetiSure (OR 2.726, 95% CI 1.532-4.852, Pâ¯=â¯0.001; OR 2.389, 95% CI 1.537-3.711, P < 0.001, respectively).CONCLUSIONS:
Semen quality, fertilization method and detection system are independent factors associated with embryonic mosaicism.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Diagnóstico Pré-Implantação
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Mosaicismo
Tipo de estudo:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Female
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Humans
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Male
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Pregnancy
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article