Nuclear TIGAR mediates an epigenetic and metabolic autoregulatory loop <i>via</i> NRF2 in cancer therapeutic resistance.

Wang, Hong; Wang, Qianqian; Cai, Guodi; Duan, Zhijian; Nugent, Zoann; Huang, Jie; Zheng, Jianwei; Borowsky, Alexander D; Li, Jian Jian; Liu, Peiqing; Kung, Hsing-Jien; Murphy, Leigh; Chen, Hong-Wu; Wang, Junjian

Nuclear TIGAR mediates an epigenetic and metabolic autoregulatory loop via NRF2 in cancer therapeutic resistance.

Wang, Hong; Wang, Qianqian; Cai, Guodi; Duan, Zhijian; Nugent, Zoann; Huang, Jie; Zheng, Jianwei; Borowsky, Alexander D; Li, Jian Jian; Liu, Peiqing; Kung, Hsing-Jien; Murphy, Leigh; Chen, Hong-Wu; Wang, Junjian.

Afiliação

Wang H; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Wang Q; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Cai G; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Duan Z; Department of Biochemistry and Molecular Medicine, University of California, Davis, Sacramento, CA 95817, USA.
Nugent Z; Research Institute in Oncology and Hematology, University of Manitoba and CancerCare Manitoba, Winnipeg R3E 0V9, Canada.
Huang J; Guangdong Lung Cancer Institute, Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou 510080, China.
Zheng J; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Borowsky AD; Department of Pathology and Laboratory Medicine, University of California, Davis, Sacramento, CA 95817, USA.
Li JJ; Department of Radiation Oncology, University of California, Davis, Sacramento, CA 95817, USA.
Liu P; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Kung HJ; National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation, Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Sun Yat-sen University, Guangzhou 510006, China.
Murphy L; Department of Biochemistry and Molecular Medicine, University of California, Davis, Sacramento, CA 95817, USA.
Chen HW; UC Davis Comprehensive Cancer Center, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA.
Wang J; Research Institute in Oncology and Hematology, University of Manitoba and CancerCare Manitoba, Winnipeg R3E 0V9, Canada.

Acta Pharm Sin B ; 12(4): 1871-1884, 2022 Apr.

Article em En | MEDLINE | ID: mdl-35847493

Palavras-chave

ARE, antioxidant response element; DoxR, doxorubicin resistant; Epigenetic reprogramming; F2,6bPase, fructose-2,6-bisphosphatase; FBS, fetal bovine serum; Metabolism; NLS, nuclear localization signal; NRF2; NRF2, NF-E2-related factor-2; NSCLC, non-small-cell lung carcinoma; NSD2; NSD2, nuclear receptor binding SET domain protein 2; Oxidative stress; PGC1α, PPARG coactivator 1 alpha; PPP, pentose phosphate pathway; RadR, ionizing radiation-resistance; Redox homeostasis; TIGAR; TIGAR, TP53-induced glycolysis and apoptosis regulator; TamR, tamoxifen resistant; Therapeutic resistance

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article