Nuclear TIGAR mediates an epigenetic and metabolic autoregulatory loop via NRF2 in cancer therapeutic resistance.
Acta Pharm Sin B
; 12(4): 1871-1884, 2022 Apr.
Article
em En
| MEDLINE
| ID: mdl-35847493
ARE, antioxidant response element; DoxR, doxorubicin resistant; Epigenetic reprogramming; F2,6bPase, fructose-2,6-bisphosphatase; FBS, fetal bovine serum; Metabolism; NLS, nuclear localization signal; NRF2; NRF2, NF-E2-related factor-2; NSCLC, non-small-cell lung carcinoma; NSD2; NSD2, nuclear receptor binding SET domain protein 2; Oxidative stress; PGC1α, PPARG coactivator 1 alpha; PPP, pentose phosphate pathway; RadR, ionizing radiation-resistance; Redox homeostasis; TIGAR; TIGAR, TP53-induced glycolysis and apoptosis regulator; TamR, tamoxifen resistant; Therapeutic resistance
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