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Disulfiram's journey from rubber vulcanization to T-cell activation.
Dosset, Magalie; Zanetti, Maurizio.
Afiliação
  • Dosset M; The Laboratory of Immunology, Department of Medicine and Moores Cancer Center, University of California, San Diego, CA, USA.
  • Zanetti M; The Laboratory of Immunology, Department of Medicine and Moores Cancer Center, University of California, San Diego, CA, USA.
EMBO J ; 41(16): e111862, 2022 08 16.
Article em En | MEDLINE | ID: mdl-35848116
Disulfiram, a drug prescribed for the treatment of alcohol use disorders for more than 60 years, has recently been repurposed for cancer treatment. New work in The EMBO Journal now describes a disulfiram role in immunotherapy of cancer, involving direct binding to Lck to mediate activation of tumor-infiltrating T cells.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dissuasores de Álcool / Alcoolismo / Neoplasias Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dissuasores de Álcool / Alcoolismo / Neoplasias Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article