High-level dolutegravir resistance can emerge rapidly from few variants and spread by recombination: implications for integrase strand transfer inhibitor salvage therapy.

Huik, Kristi; Hill, Shawn; George, Jomy; Pau, Alice; Kuriakose, Safia; Lange, Camille M; Dee, Nicola; Stoll, Pamela; Khan, Muhammad; Rehman, Tauseef; Rehm, Catherine A; Dewar, Robin; Grossman, Zehava; Maldarelli, Frank

Huik, Kristi; Hill, Shawn; George, Jomy; Pau, Alice; Kuriakose, Safia; Lange, Camille M; Dee, Nicola; Stoll, Pamela; Khan, Muhammad; Rehman, Tauseef; Rehm, Catherine A; Dewar, Robin; Grossman, Zehava; Maldarelli, Frank.

Afiliação

Huik K; National Cancer Institute, Frederick.
Hill S; National Cancer Institute, Frederick.
George J; National Institutes of Health (NIH) Clinical, Center (CC).
Pau A; National Institute of Allergy and Infectious Diseases, Bethesda.
Kuriakose S; Clinical Research Directorate/Clinical Monitoring Research Program, Leidos Biomedical Research, Inc., NCI Campus at Frederick, Frederick, MD, USA.
Lange CM; National Cancer Institute, Frederick.
Dee N; Clinical Research Directorate/Clinical Monitoring Research Program, Leidos Biomedical Research, Inc., NCI Campus at Frederick, Frederick, MD, USA.
Stoll P; National Institutes of Health (NIH) Clinical, Center (CC).
Khan M; Clinical Research Directorate/Clinical Monitoring Research Program, Leidos Biomedical Research, Inc., NCI Campus at Frederick, Frederick, MD, USA.
Rehman T; Clinical Research Directorate/Clinical Monitoring Research Program, Leidos Biomedical Research, Inc., NCI Campus at Frederick, Frederick, MD, USA.
Rehm CA; National Institute of Allergy and Infectious Diseases, Bethesda.
Dewar R; Clinical Research Directorate/Clinical Monitoring Research Program, Leidos Biomedical Research, Inc., NCI Campus at Frederick, Frederick, MD, USA.
Grossman Z; National Cancer Institute, Frederick.
Maldarelli F; School of Public Health, Tel Aviv University, Tel Aviv, Israel.

AIDS ; 36(13): 1835-1840, 2022 11 01.

Article em En | MEDLINE | ID: mdl-35848510

Assuntos

Infecções por HIV; Inibidores de Integrase de HIV; Integrase de HIV; HIV-1; Quinolonas; Farmacorresistência Viral/genética; Infecções por HIV/tratamento farmacológico; Integrase de HIV/genética; Inibidores de Integrase de HIV/farmacologia; Inibidores de Integrase de HIV/uso terapêutico; HIV-1/genética; Compostos Heterocíclicos com 3 Anéis/farmacologia; Compostos Heterocíclicos com 3 Anéis/uso terapêutico; Humanos; Mutação; Oxazinas; Piperazinas; Piridonas/uso terapêutico; Quinolonas/farmacologia; Recombinação Genética; Terapia de Salvação

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por HIV / HIV-1 / Quinolonas / Inibidores de Integrase de HIV / Integrase de HIV Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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