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Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities.
Chen, Yaozong; Sun, Lulu; Ullah, Irfan; Beaudoin-Bussières, Guillaume; Anand, Sai Priya; Hederman, Andrew P; Tolbert, William D; Sherburn, Rebekah; Nguyen, Dung N; Marchitto, Lorie; Ding, Shilei; Wu, Di; Luo, Yuhong; Gottumukkala, Suneetha; Moran, Sean; Kumar, Priti; Piszczek, Grzegorz; Mothes, Walther; Ackerman, Margaret E; Finzi, Andrés; Uchil, Pradeep D; Gonzalez, Frank J; Pazgier, Marzena.
Afiliação
  • Chen Y; Infectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4712, USA.
  • Sun L; Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
  • Ullah I; Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.
  • Beaudoin-Bussières G; Centre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada.
  • Anand SP; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC H2X 0A9, Canada.
  • Hederman AP; Centre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada.
  • Tolbert WD; Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada.
  • Sherburn R; Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA.
  • Nguyen DN; Infectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4712, USA.
  • Marchitto L; Infectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4712, USA.
  • Ding S; Infectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4712, USA.
  • Wu D; Centre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada.
  • Luo Y; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC H2X 0A9, Canada.
  • Gottumukkala S; Centre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada.
  • Moran S; Biophysics Core Facility, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  • Kumar P; Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
  • Piszczek G; Infectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4712, USA.
  • Mothes W; Biomedical Instrumentation Center, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA.
  • Ackerman ME; Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.
  • Finzi A; Biophysics Core Facility, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  • Uchil PD; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06510, USA.
  • Gonzalez FJ; Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA.
  • Pazgier M; Centre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada.
Sci Adv ; 8(28): eabn4188, 2022 Jul 15.
Article em En | MEDLINE | ID: mdl-35857504
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article