Inborn errors of immunity associated with elevated immunoglobulin E.
Ann Allergy Asthma Immunol
; 129(5): 552-561, 2022 11.
Article
em En
| MEDLINE
| ID: mdl-35872242
ABSTRACT
OBJECTIVE:
To review the characteristic clinical and laboratory features of inborn errors of immunity (IEI) that are associated with elevated immunoglobulin (Ig)E levels. DATA SOURCES Primary peer-reviewed literature. STUDY SELECTIONS Original research articles reviewed include interventional studies, retrospective studies, case-control studies, cohort studies, and review articles related to the subject matter.RESULTS:
An extensive literature review was completed to allow for comprehensive evaluation of several monogenic IEI. This review includes a description of the classic clinical features, common infections, characteristic laboratory findings, specific diagnostic methods (when applicable), and genetic basis of disease of each syndrome. A comprehensive flow diagram was created to assist them in the diagnosis and evaluation of patients with elevated IgE levels who may require evaluation for an IEI.CONCLUSION:
IEI should be considered in patients with elevated IgE levels, especially if they have recurrent infections, eczematous dermatitis, malignancy, lymphoproliferation, autoimmunity, or connective tissue abnormalities.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Imunoglobulina E
/
Autoimunidade
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article