Impact of Local Anesthetics on Cancer Behavior and Outcome during the Perioperative Period: A Review.
Medicina (Kaunas)
; 58(7)2022 Jun 30.
Article
em En
| MEDLINE
| ID: mdl-35888601
ABSTRACT
There is a growing interest regarding the impact of the perioperative period and the application of anesthetic drugs on the recurrence of cancer metastases. Among them, the use of amide-type local anesthetics seems promising since in vitro studies and animal models have shown their potential to inhibit the Intercellular Adhesion Molecule 1 (ICAM-1) expression and Src activity, which are clearly implicated in the process of inflammation and cancer metastases. This review emphasizes the potential of amide-type local anesthetics in this context.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Anestésicos Locais
/
Neoplasias
Limite:
Animals
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article