SpeedMixing: Rapid Tribochemical Synthesis and Discovery of Pharmaceutical Cocrystals without Milling or Grinding Media.
Angew Chem Int Ed Engl
; 61(41): e202206293, 2022 10 10.
Article
em En
| MEDLINE
| ID: mdl-35894150
ABSTRACT
We present SpeedMixing, a rapid blending technology, as an approach for fast mechanosynthesis and discovery of model pharmaceutical cocrystals through rapid spinning in the absence of bulk solvents and milling/grinding media. Syntheses of pharmaceutical cocrystals based on the active pharmaceutical ingredients (APIs) carbamazepine, dihydrocarbamazepine, and nicotinamide demonstrate SpeedMixing as a method for rapid, scalable, as well as controllable and selective synthesis of cocrystals, cocrystal polymorphs and stoichiomorphs, including the discovery of an unexpected methanol solvate of the archetypal cocrystal of carbamazepine and saccharin, which has eluded extensive screens over 20â
years.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sacarina
/
Metanol
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article