Advanced Oxidation Processes in Pharmaceutical Formulations: Photo-Fenton Degradation of Peptides and Proteins.
Int J Mol Sci
; 23(15)2022 Jul 27.
Article
em En
| MEDLINE
| ID: mdl-35897838
ABSTRACT
Formulations of therapeutic proteins are sensitive to photo-degradation by near UV and visible light. Mechanistically, especially the processes leading to protein modification under visible light exposure are not understood. Potentially, these processes may be triggered by a ligand to metal charge transfer in excipient-metal complexes. This article summarizes recent analytical and mechanistic work on such reactions under experimental conditions relevant to pharmaceutical formulations.
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Base de dados:
MEDLINE
Assunto principal:
Poluentes Químicos da Água
/
Peróxido de Hidrogênio
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article