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Activation, but not inhibition, of the indirect pathway disrupts choice rejection in a freely moving, multiple-choice foraging task.
Delevich, Kristen; Hoshal, Benjamin; Zhou, Lexi Z; Zhang, Yuting; Vedula, Satya; Lin, Wan Chen; Chase, Juliana; Collins, Anne G E; Wilbrecht, Linda.
Afiliação
  • Delevich K; Department of Psychology, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Integrative Physiology and Neuroscience, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA.
  • Hoshal B; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
  • Zhou LZ; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
  • Zhang Y; Department of Psychology, University of California, Berkeley, Berkeley, CA 94720, USA.
  • Vedula S; Department of Psychology, University of California, Berkeley, Berkeley, CA 94720, USA.
  • Lin WC; Department of Psychology, University of California, Berkeley, Berkeley, CA 94720, USA; Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
  • Chase J; Department of Psychology, University of California, Berkeley, Berkeley, CA 94720, USA.
  • Collins AGE; Department of Psychology, University of California, Berkeley, Berkeley, CA 94720, USA; Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
  • Wilbrecht L; Department of Psychology, University of California, Berkeley, Berkeley, CA 94720, USA; Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: wilbrecht@berkeley.edu.
Cell Rep ; 40(4): 111129, 2022 07 26.
Article em En | MEDLINE | ID: mdl-35905722
ABSTRACT
The dorsomedial striatum (DMS) plays a key role in action selection, but less is known about how direct and indirect pathway spiny projection neurons (dSPNs and iSPNs, respectively) contribute to choice rejection in freely moving animals. Here, we use pathway-specific chemogenetic manipulation during a serial choice foraging task to test the role of dSPNs and iSPNs in learned choice rejection. We find that chemogenetic activation, but not inhibition, of iSPNs disrupts rejection of nonrewarded choices, contrary to predictions of a simple "select/suppress" heuristic. Our findings suggest that iSPNs' role in stopping and freezing does not extend in a simple fashion to choice rejection in an ethological, freely moving context. These data may provide insights critical for the successful design of interventions for addiction or other conditions in which it is desirable to strengthen choice rejection.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Corpo Estriado / Neurônios Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Corpo Estriado / Neurônios Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article