Constitutive androstane receptor (CAR) mediates pyrene-induced inflammatory responses in mouse liver, with increased serum amyloid A proteins and Th17 cells.

Shi, Zhe; Li, Xue; Zhang, Yu-Man; Zhou, Yi-Yao; Gan, Xiu-Feng; Fan, Qiao-Ying; He, Chen-Qing; Shi, Tong; Zhang, Shu-Yun

Shi, Zhe; Li, Xue; Zhang, Yu-Man; Zhou, Yi-Yao; Gan, Xiu-Feng; Fan, Qiao-Ying; He, Chen-Qing; Shi, Tong; Zhang, Shu-Yun.

Afiliação

Shi Z; Department of Preventive Medicine, School of Public Health and Management, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Li X; Department of Preventive Medicine, School of Public Health and Management, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Zhang YM; Department of Preventive Medicine, School of Public Health and Management, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Zhou YY; Department of Preventive Medicine, School of Public Health and Management, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Gan XF; Department of Preventive Medicine, School of Public Health and Management, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Fan QY; Department of Preventive Medicine, School of Public Health and Management, Wenzhou Medical University, Wenzhou, Zhejiang, China.
He CQ; Department of Preventive Medicine, School of Public Health and Management, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Shi T; School of Medicine, Tongji University, Shanghai, China.
Zhang SY; Department of Preventive Medicine, School of Public Health and Management, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Br J Pharmacol ; 179(23): 5209-5221, 2022 12.

Article em En | MEDLINE | ID: mdl-35906855

Assuntos

Receptor Constitutivo de Androstano; Pirenos; Animais; Camundongos; Receptor Constitutivo de Androstano/metabolismo; Interleucina-17; Interleucina-6; Fígado/metabolismo; Camundongos Endogâmicos C57BL; Camundongos Knockout; Pirenos/toxicidade; Receptores Citoplasmáticos e Nucleares/genética; Receptores Citoplasmáticos e Nucleares/metabolismo; Proteína Amiloide A Sérica/metabolismo; Células Th17; Xenobióticos/toxicidade

Palavras-chave

Th17 cells; constitutive androstane receptor (CAR); inflammation; polycyclic aromatic hydrocarbons (PAHs); pyrene; serum amyloid A protein (SAA)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirenos / Receptor Constitutivo de Androstano Tipo de estudo: Screening_studies Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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