Conversion of oxadiazolo[3,4-b]pyrazines to imidazo[4,5-b]pyrazines via a tandem reduction-cyclization sequence generates new mitochondrial uncouplers.

Dai, Yumin; Santiago-Rivera, José A; Hargett, Stefan; Salamoun, Joseph M; Hoehn, Kyle L; Santos, Webster L

Dai, Yumin; Santiago-Rivera, José A; Hargett, Stefan; Salamoun, Joseph M; Hoehn, Kyle L; Santos, Webster L.

Afiliação

Dai Y; Department of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, VA 24061, United States.
Santiago-Rivera JA; Department of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, VA 24061, United States.
Hargett S; Departments of Pharmacology and Medicine, University of Virginia, Charlottesville, VA 22908, United States.
Salamoun JM; Department of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, VA 24061, United States.
Hoehn KL; Departments of Pharmacology and Medicine, University of Virginia, Charlottesville, VA 22908, United States; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington, NSW 2033, Australia.
Santos WL; Department of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, VA 24061, United States. Electronic address: santosw@vt.edu.

Bioorg Med Chem Lett ; 73: 128912, 2022 10 01.

Article em En | MEDLINE | ID: mdl-35907607

Assuntos

Mitocôndrias; Pirazinas; Ciclização; Mitocôndrias/metabolismo; Oxidiazóis/metabolismo; Pirazinas/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirazinas / Mitocôndrias Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo

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XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirazinas / Mitocôndrias Idioma: En Ano de publicação: 2022 Tipo de documento: Article