Reductive SN 2' Reaction of Epoxydienoate with Borane and its Application to the Synthesis and Structural Revision of an Antitumor Active Torrubiellutin Analogue.
Chem Asian J
; 17(18): e202200650, 2022 Sep 14.
Article
em En
| MEDLINE
| ID: mdl-35909083
ABSTRACT
A reductive SN 2' reaction of epoxydienoates and epoxyenoates with borane was developed to afford skipped dienoates and unconjugated enoates with trisubstituted Z-alkene linked to asymmetric centers on one side or both sides. This reaction was successfully applied to the alternative synthesis of an antitumor active artificial analogue of torrubiellutin C. A geometric isomer for α,ß-unsaturated amide of the artificial analogue was also synthesized. These syntheses clarified the true structure of the antitumor active artificial analogue of torrubiellutin C.
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MEDLINE
Assunto principal:
Boranos
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article