Diet-induced inflammation in the anterior paraventricular thalamus induces compulsive sucrose-seeking.
Nat Neurosci
; 25(8): 1009-1013, 2022 08.
Article
em En
| MEDLINE
| ID: mdl-35915173
ABSTRACT
Overconsumption of palatable food may initiate neuroadaptive responses in brain reward circuitry that may contribute to eating disorders. Here we report that high-fat diet (HFD) consumption impedes threat-cue-induced suppression of sucrose-seeking in mice. This compulsive sucrose-seeking was due to enhanced cue-triggered neuronal activity in the anterior paraventricular thalamus (aPVT) resulting from HFD-induced microglia activation. Thus, metabolic inflammation in the aPVT produces an adaptive response to threat cues, leading to compulsive food-seeking.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sacarose
/
Núcleos Anteriores do Tálamo
Limite:
Animals
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article