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Diet-induced inflammation in the anterior paraventricular thalamus induces compulsive sucrose-seeking.
Cheng, Jingjing; Ma, Xiaolin; Li, Chunlu; Ullah, Rahim; Wang, Xiaoyu; Long, Jianmei; Yuan, Zhenxin; Liu, Shuangshuang; Fu, Junfen; Chen, Zhong; Shen, Yi; Zhou, Yu-Dong.
Afiliação
  • Cheng J; Institute of Neuroscience, NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Research and Brain-Machine Integration, Zhejiang University School of Brain Science and Brain Medicine, Hangzhou, China.
  • Ma X; Department of Ophthalmology of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
  • Li C; Laboratory Medicine Center, Department of Transfusion Medicine, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, China.
  • Ullah R; Institute of Neuroscience, NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Research and Brain-Machine Integration, Zhejiang University School of Brain Science and Brain Medicine, Hangzhou, China.
  • Wang X; Department of Ophthalmology of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
  • Long J; Institute of Neuroscience, NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Research and Brain-Machine Integration, Zhejiang University School of Brain Science and Brain Medicine, Hangzhou, China.
  • Yuan Z; Department of Psychology, School of Medical Humanitarians, Guizhou Medical University, Guiyang, China.
  • Liu S; Institute of Neuroscience, NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Research and Brain-Machine Integration, Zhejiang University School of Brain Science and Brain Medicine, Hangzhou, China.
  • Fu J; Department of Endocrinology, Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
  • Chen Z; Institute of Neuroscience, NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Research and Brain-Machine Integration, Zhejiang University School of Brain Science and Brain Medicine, Hangzhou, China.
  • Shen Y; Department of Ophthalmology of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
  • Zhou YD; Institute of Neuroscience, NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Research and Brain-Machine Integration, Zhejiang University School of Brain Science and Brain Medicine, Hangzhou, China.
Nat Neurosci ; 25(8): 1009-1013, 2022 08.
Article em En | MEDLINE | ID: mdl-35915173
ABSTRACT
Overconsumption of palatable food may initiate neuroadaptive responses in brain reward circuitry that may contribute to eating disorders. Here we report that high-fat diet (HFD) consumption impedes threat-cue-induced suppression of sucrose-seeking in mice. This compulsive sucrose-seeking was due to enhanced cue-triggered neuronal activity in the anterior paraventricular thalamus (aPVT) resulting from HFD-induced microglia activation. Thus, metabolic inflammation in the aPVT produces an adaptive response to threat cues, leading to compulsive food-seeking.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sacarose / Núcleos Anteriores do Tálamo Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sacarose / Núcleos Anteriores do Tálamo Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article