The histone deacetylase SIRT6 promotes glycolysis through the HIF-1&#945;/HK2 signaling axis and induces erlotinib resistance in non-small cell lung cancer.

You, Qiai; Wang, Jianmin; Yu, Yongxin; Li, Feng; Meng, Lingxin; Chen, Mingjing; Yang, Qiao; Xu, Zihan; Sun, Jianguo; Zhuo, Wenlei; Chen, Zhengtang

The histone deacetylase SIRT6 promotes glycolysis through the HIF-1α/HK2 signaling axis and induces erlotinib resistance in non-small cell lung cancer.

You, Qiai; Wang, Jianmin; Yu, Yongxin; Li, Feng; Meng, Lingxin; Chen, Mingjing; Yang, Qiao; Xu, Zihan; Sun, Jianguo; Zhuo, Wenlei; Chen, Zhengtang.

Afiliação

You Q; Institute of Cancer, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.
Wang J; Institute of Cancer, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.
Yu Y; Institute of Cancer, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.
Li F; Institute of Cancer, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.
Meng L; Institute of Cancer, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.
Chen M; Institute of Cancer, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.
Yang Q; Institute of Cancer, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.
Xu Z; Institute of Cancer, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.
Sun J; Institute of Cancer, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.
Zhuo W; Institute of Cancer, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China. zhuowenlei@tmmu.edu.cn.
Chen Z; Institute of Cancer, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China. czt__05@163.com.

Apoptosis ; 27(11-12): 883-898, 2022 12.

Article em En | MEDLINE | ID: mdl-35915188

Assuntos

Carcinoma Pulmonar de Células não Pequenas; Neoplasias Pulmonares; Sirtuínas; Animais; Camundongos; Apoptose; Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico; Carcinoma Pulmonar de Células não Pequenas/genética; Carcinoma Pulmonar de Células não Pequenas/patologia; Linhagem Celular Tumoral; Resistencia a Medicamentos Antineoplásicos/genética; Receptores ErbB/genética; Receptores ErbB/metabolismo; Cloridrato de Erlotinib/farmacologia; Cloridrato de Erlotinib/uso terapêutico; Glicólise/genética; Histona Desacetilases/metabolismo; Neoplasias Pulmonares/tratamento farmacológico; Neoplasias Pulmonares/genética; Neoplasias Pulmonares/patologia; Mutação; Inibidores de Proteínas Quinases/farmacologia; Sirtuínas/genética; Sirtuínas/metabolismo; Ensaios Antitumorais Modelo de Xenoenxerto; Humanos

Palavras-chave

EGFR-TKI; Erlotinib; Glycolysis; NSCLC; SIRT6

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Sirtuínas / Neoplasias Pulmonares Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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