[6]-Gingerol induces Caspase-Dependent Apoptosis in Bladder Cancer cells via MAPK and ROS Signaling.
Int J Med Sci
; 19(7): 1093-1102, 2022.
Article
em En
| MEDLINE
| ID: mdl-35919815
ABSTRACT
The anti-cancer effects of [6]-gingerol ([6]-GIN), the main active polyphenol of ginger (Zingiber officinale), were investigated in the human bladder cancer cell line 5637. [6]-GIN inhibited cell proliferation, increased subG1 phase ratios, and depolarized mitochondrial membrane potential. [6]-GIN-induced cell death was associated with the downregulation of Bcell lymphoma 2 (BCL2) and survivin and the upregulation of Bcl2associated X protein (Bax). [6]-GIN activated caspase3 and caspase-9 and regulated the activation of mitogen-activated protein kinases (MAPKs). Further, [6]-GIN also increased the intracellular reactive oxygen species (ROS) levels and TG100-115 or tranilast increased [6]-GINinduced cell death. These results suggest that [6]-GIN induced apoptosis in the bladder cancer cell line 5637 and therefore has the potential to be used in the development of new drugs for bladder cancer treatment.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Bexiga Urinária
/
Zingiber officinale
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article