Acute, repeated inhalation toxicity, respiratory system irritation, and mutagenicity studies of 1,1,2,2-tetrafluoroethane (HFC-134) as the impurity in the pharmaceutical propellant 1,1,1,2-tetrafluoroethane (HFA-134a).

Zhao, Yanjun; Sun, Huimin; Lin, Fei; Yang, Huiying

Zhao, Yanjun; Sun, Huimin; Lin, Fei; Yang, Huiying.

Afiliação

Zhao Y; NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients, Beijing, China.
Sun H; National Institutes for Food and Drug Control, Beijing, China.
Lin F; NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients, Beijing, China.
Yang H; National Institutes for Food and Drug Control, Beijing, China.

Drug Chem Toxicol ; 46(5): 841-850, 2023 Nov.

Article em En | MEDLINE | ID: mdl-35920286

Assuntos

Propelentes de Aerossol; Mutagênicos; Masculino; Ratos; Feminino; Animais; Propelentes de Aerossol/toxicidade; Ratos Sprague-Dawley; Hidrocarbonetos Fluorados/toxicidade; Administração por Inalação; Sistema Respiratório

Palavras-chave

HFC-134; HFC-134a; Metered-dose inhaler; inhalation toxicology; propellant

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Propelentes de Aerossol / Mutagênicos Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google