Optogenetically induced reward and 'frustration' memory in larval Drosophila melanogaster.
J Exp Biol
; 225(16)2022 08 15.
Article
em En
| MEDLINE
| ID: mdl-35924545
ABSTRACT
Animals, including humans, form oppositely valenced memories for stimuli that predict the occurrence versus the termination of a reward appetitive 'reward' memory for stimuli associated with the occurrence of a reward and aversive 'frustration' memory for stimuli that are associated with its termination. We characterized these memories in larval Drosophila melanogaster using a combination of Pavlovian conditioning, optogenetic activation of the dopaminergic central-brain DAN-i1864 neuron, and high-resolution video-tracking. This reveals their dependency on the number of training trials and the duration of DAN-i1864 activation, their temporal stability, and the parameters of locomotion that are modulated during memory expression. Together with previous results on 'punishment' versus 'relief' learning by DAN-f1 neuron activation, this reveals a 2×2 matrix of timing-dependent memory valence for the occurrence/termination of reward/punishment. These findings should aid the understanding and modelling of how brains decipher the predictive, causal structure of events around a target reinforcing occurrence.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Corpos Pedunculados
/
Drosophila melanogaster
Tipo de estudo:
Prognostic_studies
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article