AP-1 transcription factor network explains diverse patterns of cellular plasticity in melanoma cells.

Comandante-Lou, Natacha; Baumann, Douglas G; Fallahi-Sichani, Mohammad

Comandante-Lou, Natacha; Baumann, Douglas G; Fallahi-Sichani, Mohammad.

Afiliação

Comandante-Lou N; Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Baumann DG; Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA.
Fallahi-Sichani M; Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA; UVA Cancer Center, University of Virginia, Charlottesville, VA 22908, USA. Electronic address: fallahi@virginia.edu.

Cell Rep ; 40(5): 111147, 2022 08 02.

Article em En | MEDLINE | ID: mdl-35926467

Assuntos

Melanoma; Fator de Transcrição AP-1; Linhagem Celular Tumoral; Plasticidade Celular; Regulação da Expressão Gênica; Humanos; Melanoma/patologia; Inibidores de Proteínas Quinases/farmacologia; Fator de Transcrição AP-1/metabolismo

Palavras-chave

AP-1 transcription factors; BRAF-mutant melanoma; CP: Cancer; CP: Molecular biology; MAPK signaling pathway; adaptive drug resistance; cellular plasticity; computational modeling; differentiation state heterogeneity; single-cell analysis; statistical learning; targeted therapies

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fator de Transcrição AP-1 / Melanoma Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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