Use of biomarker data and metabolite relative potencies to support derivation of noncancer reference values based on the reproductive and developmental toxicity effects of 1,3-butadiene.

Kirman, C R; North, C M; Tretyakova, N Y; Erraguntla, N; Shen, H; Hays, S M

Kirman, C R; North, C M; Tretyakova, N Y; Erraguntla, N; Shen, H; Hays, S M.

Afiliação

Kirman CR; Summit Toxicology, Bozeman, MT, USA. Electronic address: ckirman@summittoxicology.com.
North CM; ExxonMobil Biomedical, Annandale, NJ, USA.
Tretyakova NY; University of Minnesota, Twin Cities, MN, USA.
Erraguntla N; American Chemistry Council, Arlington, VA, USA.
Shen H; Shell Oil Company, Houston, TX, USA.
Hays SM; Summit Toxicology, Bozeman, MT, USA.

Regul Toxicol Pharmacol ; 134: 105239, 2022 Oct.

Article em En | MEDLINE | ID: mdl-35926658

Assuntos

Butadienos; Reprodução; Animais; Biomarcadores; Butadienos/metabolismo; Butadienos/toxicidade; Humanos; Camundongos; Ratos; Valores de Referência

Palavras-chave

1,3-Butadiene; Benchmark dose; Biomarkers; Data derived extrapolation factors; Hemoglobin adducts; Internal dose; Metabolism; Mixtures assessment; Noncancer reference concentration; Pooled analysis; Species differences

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Reprodução / Butadienos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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