Effects of ceramide kinase knockout on lipopolysaccharide-treated sepsis-model mice: Changes in serum cytokine/chemokine levels and increased lethality.

Tanaka, Ai; Honda, Takuya; Yasue, Masataka; Yamazaki, Risa; Hatakeyama, Hiroto; Hisaka, Akihiro; Mashimo, Masato; Kohama, Takafumi; Nakamura, Hiroyuki; Murayama, Toshihiko

Tanaka, Ai; Honda, Takuya; Yasue, Masataka; Yamazaki, Risa; Hatakeyama, Hiroto; Hisaka, Akihiro; Mashimo, Masato; Kohama, Takafumi; Nakamura, Hiroyuki; Murayama, Toshihiko.

Afiliação

Tanaka A; Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260-8675, Japan.
Honda T; Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260-8675, Japan.
Yasue M; Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260-8675, Japan.
Yamazaki R; Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260-8675, Japan.
Hatakeyama H; Laboratory of Clinical Pharmacology and Pharmacometrics, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260-8675, Japan.
Hisaka A; Laboratory of Clinical Pharmacology and Pharmacometrics, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260-8675, Japan.
Mashimo M; Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kyoto 610-0332, Japan.
Kohama T; Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260-8675, Japan.
Nakamura H; Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260-8675, Japan. Electronic address: nakahiro@faculty.chiba-u.jp.
Murayama T; Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260-8675, Japan.

J Pharmacol Sci ; 150(1): 1-8, 2022 Sep.

Article em En | MEDLINE | ID: mdl-35926944

Assuntos

Lipopolissacarídeos; Sepse; Animais; Ceramidas/metabolismo; Quimiocinas; Citocinas; Deleção de Genes; Camundongos; Camundongos Knockout; Fosfotransferases (Aceptor do Grupo Álcool)/genética; Fosfotransferases (Aceptor do Grupo Álcool)/metabolismo; Sepse/genética

Palavras-chave

Ceramide-1-phosphate; Interleukin-17; Monocyte chemotactic protein-1 (MCP-1); Neutrophils; Tumor necrosis factor-α

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Lipopolissacarídeos / Sepse Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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