Six New Polyoxygenated Xanthones from Garcinia cowa and Their Neuroprotective Effects on Glutamate-Mediated Hippocampal Neuronal HT22 Cell Death.
Chem Biodivers
; 19(9): e202200376, 2022 Sep.
Article
em En
| MEDLINE
| ID: mdl-35927784
ABSTRACT
Six new polyoxygenated xanthones, garcicowanones F-H (1-3), norcowanol A-B (4-5), and garcinoneâ
F (6) along with twelve known compounds 7-18 were obtained from the latex of Garcinia cowa Roxb. ex Choisy. All new compounds have a 1,3,7-trioxygenated or 1,3,6,7-tetraoxygenated xanthone nucleus and differ from majority of xanthones from G.â
cowa by hydrated side chains. Compoundsâ
1, 7, 8 and 18 exhibited significant neuroprotective effects on glutamate-mediated hippocampal neuronal HT22 cell death. In particular, compound 1 exhibited the most potent neuroprotective effect with >80 % cell viability in the concentration range of 2.9-115â
µM. Further studies on compound 1 showed that it decreased cellular Ca2+ influx and inhibits cellular reactive oxygen species generation in HT22 cells. A Western blot analysis showed that MAPK phosphorylation, Bax, and AIF translocation dramatically increased upon treatment with 5â
mM glutamate and decreased upon a co-treatment with compound 1.
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Base de dados:
MEDLINE
Assunto principal:
Fármacos Neuroprotetores
/
Garcinia
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Xantonas
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article