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Value of the prognostic nutritional index (PNI) in patients with newly diagnosed, CD5-positive diffuse large B-cell lymphoma: A multicenter retrospective study of the Huaihai Lymphoma Working Group.
Ma, Sha; Zhang, Bingpei; Lu, Tianyi; Li, Dashan; Li, Tianci; Shen, Ziyuan; He, Chenlu; Wang, Ying; Li, Bingzong; Zhang, Hao; Gu, Weiying; Wang, Chunling; Ye, Jingjing; Zhu, Taigang; Miao, Yuqing; Wang, Ling; Huang, Shuiping; Liu, Qinhua; Sang, Wei.
Afiliação
  • Ma S; Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.
  • Zhang B; Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.
  • Lu T; Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.
  • Li D; Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.
  • Li T; Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.
  • Shen Z; Department of Epidemiology and Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, Jiangsu, China.
  • He C; Department of Epidemiology and Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, Jiangsu, China.
  • Wang Y; Department of Personnel, Suqian First Hospital, Suqian, Jiangsu, China.
  • Li B; Department of Hematology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
  • Zhang H; Department of Hematology, The Affiliated Hospital of Jining Medical University, Jining, Shandong, China.
  • Gu W; Department of Hematology, The First People's Hospital of Changzhou, Changzhou, Jiangsu, China.
  • Wang C; Department of Hematology, Huai'an First People's Hospital, Huai'an Jiangsu, China.
  • Ye J; Department of Hematology, Qilu Hospital of Shandong University, Jinan, Shandong, China.
  • Zhu T; Department of Hematology, The General Hospital of Wanbei Coal-Electric Group, Suzhou, Anhui, China.
  • Miao Y; Department of Hematology, Yancheng First People's Hospital, Yancheng, Jiangsu, China.
  • Wang L; Department of Hematology, Taian Central Hospital, Taian, Shandong, China.
  • Huang S; Department of Epidemiology and Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, Jiangsu, China.
  • Liu Q; Center for Medical Statistics and Data Analysis, School of Public Health, Xuzhou Medical University, Xuzhou, Jiangsu, China.
  • Sang W; Department of Hematology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Cancer ; 128(19): 3487-3494, 2022 10 01.
Article em En | MEDLINE | ID: mdl-35932292
BACKGROUND: CD5-positive diffuse large B-cell lymphoma (DLBCL) is a clinically rare subtype of DLBCL with aggressive clinical manifestations and a poor prognosis. It has been demonstrated that the prognostic nutritional index (PNI), an indicator of nutritional status and systemic inflammation, is a significant prognostic factor for several types of lymphoma. The objective of this multicenter retrospective study was to explore the prognostic value of the PNI in patients with CD5-positive DLBCL. METHODS: In total, 207 patients with CD5-positive DLBCL were recruited from 11 centers of the Huaihai Lymphoma Working Group. Maximally selected rank statistics analysis was used to identify optimal cutoff points for the PNI. A Cox proportional hazards model was used for univariable and multivariable analyses. Kaplan-Meier curves were used to calculate survival rates and draw survival curves, and the log-rank test was used to compare differences between groups. RESULTS: The median age at diagnosis was 61 years, and the 5-year overall survival rate was 47.5%. According to the maximally selected rank statistics analysis, a score of 49.7 was the optimal cutoff point for the PNI. Subgroup analysis showed that the PNI could re-stratify patients in BCL-2-negative, MYC-negative, high-intermediate-risk and high-risk International Prognostic Index, BCL-6-positive and BCL-6-negative, high Ki-67 score (≥0.9), Ann Arbor stage III/IV, Eastern Cooperative Oncology Group performance status ≥2, and germinal center B subgroups. Multivariable analysis revealed that PNI, age, Eastern Cooperative Oncology Group performance status, albumin level, and red blood cell count were independent prognostic factors for CD5-positive DLBCL. CONCLUSIONS: The PNI was a significant prognostic indicator for CD5-positive DLBCL and was able to re-stratify the prognosis for clinicopathologic subgroups of patients with CD5-positive DLBCL.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Avaliação Nutricional / Linfoma Difuso de Grandes Células B Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Avaliação Nutricional / Linfoma Difuso de Grandes Células B Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article