Biased GPCR signaling by the native parathyroid hormone-related protein 1 to 141 relative to its N-terminal fragment 1 to 36.

Peña, Karina A; White, Alex D; Savransky, Sofya; Castillo, Ignacio Portales; Jean-Alphonse, Frédéric G; Gardella, Thomas J; Sutkeviciute, Ieva; Vilardaga, Jean-Pierre

Peña, Karina A; White, Alex D; Savransky, Sofya; Castillo, Ignacio Portales; Jean-Alphonse, Frédéric G; Gardella, Thomas J; Sutkeviciute, Ieva; Vilardaga, Jean-Pierre.

Afiliação

Peña KA; School of Medicine, Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, USA.
White AD; School of Medicine, Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, USA.
Savransky S; School of Medicine, Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, USA; Graduate Program in Molecular Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, USA.
Castillo IP; Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Jean-Alphonse FG; School of Medicine, Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, USA.
Gardella TJ; Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Sutkeviciute I; School of Medicine, Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, USA.
Vilardaga JP; School of Medicine, Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, USA. Electronic address: jpv@pitt.edu.

J Biol Chem ; 298(9): 102332, 2022 09.

Article em En | MEDLINE | ID: mdl-35933010

Assuntos

Receptor Tipo 1 de Hormônio Paratireóideo; AMP Cíclico/metabolismo; Heparina/metabolismo; Humanos; Ligantes; Conformação Proteica; Receptor Tipo 1 de Hormônio Paratireóideo/química; Receptor Tipo 1 de Hormônio Paratireóideo/metabolismo; Transdução de Sinais; beta-Arrestinas/metabolismo

Palavras-chave

GPCR; PTH receptor; cAMP signaling; location bias signaling; parathyroid hormonerelated protein

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptor Tipo 1 de Hormônio Paratireóideo Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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