RNF2 mediates pulmonary fibroblasts activation and proliferation by regulating mTOR and p16-CDK4-Rb1 signaling pathway.

Pan, Linxin; Hu, Ying; Qian, Cheng; Yao, Yan; Wang, Shuxian; Shi, Wanrong; Xu, Tao

Pan, Linxin; Hu, Ying; Qian, Cheng; Yao, Yan; Wang, Shuxian; Shi, Wanrong; Xu, Tao.

Afiliação

Pan L; School of Life Science, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, People's Republic of China.
Hu Y; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, School of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, People's Republic of China.
Qian C; Institute for Liver Diseases of Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, People's Republic of China.
Yao Y; Center for Scientific Research, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, People's Republic of China.
Wang S; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, School of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, People's Republic of China.
Shi W; Institute for Liver Diseases of Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, People's Republic of China.
Xu T; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, School of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, People's Republic of China.

Inflamm Res ; 71(10-11): 1283-1303, 2022 Nov.

Article em En | MEDLINE | ID: mdl-35933565

Assuntos

Fibrose Pulmonar; Fator de Crescimento Transformador beta1; Camundongos; Humanos; Animais; Fator de Crescimento Transformador beta1/metabolismo; Fibrose Pulmonar/induzido quimicamente; Fibrose Pulmonar/metabolismo; Transdução de Sinais; Pulmão/patologia; Bleomicina/efeitos adversos; Bleomicina/metabolismo; Serina-Treonina Quinases TOR; Fibroblastos/metabolismo; Proliferação de Células; Complexo Repressor Polycomb 1/metabolismo; Complexo Repressor Polycomb 1/farmacologia; Quinase 4 Dependente de Ciclina/metabolismo; Quinase 4 Dependente de Ciclina/farmacologia; Ubiquitina-Proteína Ligases

Palavras-chave

ECM; Fibroblasts; PF; RNF2; mTOR

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fibrose Pulmonar / Fator de Crescimento Transformador beta1 Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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