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Discovery of 1-(Hetero)aryl-ß-carboline Derivatives as IDO1/TDO Dual Inhibitors with Antidepressant Activity.
Zhang, Yu; Li, Yingchun; Chen, Xiang; Chen, Xuan; Chen, Chao; Wang, Li; Dong, Xu; Wang, Guoli; Gu, Ruxin; Li, Fei; Han, Feng; Chen, Dongyin.
Afiliação
  • Zhang Y; Key Laboratory of Cardiovascular & Cerebrovascular Medicine, Drug Target and Drug Discovery Center, School of Pharmacy, Nanjing Medical University, Nanjing 211166, China.
  • Li Y; Department of Medicinal Chemistry, School of Pharmacy, Nanjing Medical University, Nanjing 211166, China.
  • Chen X; Department of Medicinal Chemistry, School of Pharmacy, Nanjing Medical University, Nanjing 211166, China.
  • Chen X; Department of Medicinal Chemistry, School of Pharmacy, Nanjing Medical University, Nanjing 211166, China.
  • Chen C; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
  • Wang L; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
  • Dong X; Department of Medicinal Chemistry, School of Pharmacy, Nanjing Medical University, Nanjing 211166, China.
  • Wang G; Department of Medicinal Chemistry, School of Pharmacy, Nanjing Medical University, Nanjing 211166, China.
  • Gu R; Institute of Brain Science, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing 211166, China.
  • Li F; Department of Medicinal Chemistry, School of Pharmacy, Nanjing Medical University, Nanjing 211166, China.
  • Han F; Key Laboratory of Cardiovascular & Cerebrovascular Medicine, Drug Target and Drug Discovery Center, School of Pharmacy, Nanjing Medical University, Nanjing 211166, China.
  • Chen D; Institute of Brain Science, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing 211166, China.
J Med Chem ; 65(16): 11214-11228, 2022 08 25.
Article em En | MEDLINE | ID: mdl-35938398
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Indolamina-Pirrol 2,3,-Dioxigenase / Cinurenina Tipo de estudo: Guideline Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Indolamina-Pirrol 2,3,-Dioxigenase / Cinurenina Tipo de estudo: Guideline Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article