Mechanisms involved in hematopoietic stem cell aging.
Cell Mol Life Sci
; 79(9): 473, 2022 Aug 08.
Article
em En
| MEDLINE
| ID: mdl-35941268
ABSTRACT
Hematopoietic stem cells (HSCs) undergo progressive functional decline over time due to both internal and external stressors, leading to aging of the hematopoietic system. A comprehensive understanding of the molecular mechanisms underlying HSC aging will be valuable in developing novel therapies for HSC rejuvenation and to prevent the onset of several age-associated diseases and hematological malignancies. This review considers the general causes of HSC aging that range from cell-intrinsic factors to cell-extrinsic factors. In particular, epigenetics and inflammation have been implicated in the linkage of HSC aging, clonality, and oncogenesis. The challenges in clarifying mechanisms of HSC aging have accelerated the development of therapeutic interventions to rejuvenate HSCs, the major goal of aging research; these details are also discussed in this review.
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Base de dados:
MEDLINE
Assunto principal:
Células-Tronco Hematopoéticas
/
Senescência Celular
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article