Cp*RhIII-Catalyzed Cascade Annulation of Arylimidates with Pyridotriazoles toward Isoquinolin-3-ol Derivatives.
J Org Chem
; 87(16): 10858-10868, 2022 Aug 19.
Article
em En
| MEDLINE
| ID: mdl-35948053
ABSTRACT
A Cp*RhIII-catalyzed efficient synthesis of isoquinolin-3-ol derivatives bearing a pyridinyl ring using imidate as a directing group under C-H activation strategy with pyridotriazoles as carbene reagents is reported. In this reaction, cascade C-H activation, regioselective cyclization, and elimination occur in one pot. The present methodology featured a good range of functional group tolerance and furnished the target products in moderate-to-excellent yields.
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MEDLINE
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En
Ano de publicação:
2022
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Article