Inhibition of NLRP1-Dependent Pyroptosis Prevents Glycogen Synthase Kinase-3ß Overactivation-Induced Hyperphosphorylated Tau in Rats.

Liu, Xiangying; Song, Wenjing; Yu, Ying; Su, Jianhua; Shi, Xiaoyan; Yang, Xin; Wang, Honghui; Liu, Peng; Zou, Libo

Liu, Xiangying; Song, Wenjing; Yu, Ying; Su, Jianhua; Shi, Xiaoyan; Yang, Xin; Wang, Honghui; Liu, Peng; Zou, Libo.

Afiliação

Liu X; Department of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China.
Song W; Department of Pharmacology, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China.
Yu Y; Liaoning Medical Device Test Institute, 600-1 Maizitun, Hunnan District, Shenyang, 110171, China.
Su J; Department of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China.
Shi X; Department of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China.
Yang X; Department of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China.
Wang H; Department of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China.
Liu P; Department of Pharmacology, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China. pengliu@syphu.edu.cn.
Zou L; Department of Pharmacology, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China. libozou@163.com.

Neurotox Res ; 40(5): 1163-1173, 2022 Oct.

Article em En | MEDLINE | ID: mdl-35951283

Assuntos

Interleucina-18; Proteínas tau; Animais; Caspases/metabolismo; Proteínas Quinases Dependentes de AMP Cíclico/metabolismo; Glicogênio Sintase Quinase 3 beta/metabolismo; Interleucina-18/metabolismo; Interleucina-18/farmacologia; Aprendizagem em Labirinto; Proteínas do Tecido Nervoso; Fosfatidilinositol 3-Quinases/metabolismo; Fosforilação; Piroptose; RNA Interferente Pequeno/metabolismo; Ratos; Estreptozocina; Wortmanina/farmacologia; Proteínas tau/metabolismo

Palavras-chave

GSK3ß; Hyperphosphorylated tau; NLRP1; Pyroptosis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas tau / Interleucina-18 Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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