Modification of Pyrrolo[2,1-a]isoquinolines and Polysubstituted Pyrroles via Methylenation with Acetyl Chloride and Dimethylsulfoxide.
J Org Chem
; 87(17): 11491-11502, 2022 09 02.
Article
em En
| MEDLINE
| ID: mdl-35951357
A convenient synthesis of methylene-bridged pyrrolo[2,1-a]isoquinolines has been developed. Treatment of pyrroloisoquinolines with acetyl chloride and dimethylsulfoxide (DMSO) at ambient temperature afforded bispyrroloisoquinolylmethanes in 17-85% yields. This reaction system can also be expanded to the synthesis of bispyrrolylmethanes (34-94% yields). Easy chemical transformation of methylene-bridged pyrroloisoquinoline provided an unsymmetric acid and amide possessing a privileged framework.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pirróis
/
Isoquinolinas
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article