First Experimental Evidence for Reversibility of Ammonia Loss from Asparagine.
Int J Mol Sci
; 23(15)2022 Jul 28.
Article
em En
| MEDLINE
| ID: mdl-35955504
ABSTRACT
Ammonia loss from L-asparaginyls is a nonenzymatic reaction spontaneously occurring in all proteins and eventually resulting in damaging isoaspartate residues that hamper protein function and induce proteinopathy related to aging. Here, we discuss theoretical considerations supporting the possibility of a full repair reaction and present the first experimental evidence of its existence. If confirmed, the true repair of L-asparaginyl deamidation could open new avenues for preventing aging and neurodegenerative diseases.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Asparagina
/
Doenças Neurodegenerativas
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article