Relationship between Brain Metabolic Disorders and Cognitive Impairment: LDL Receptor Defect.

Hong, Dong-Yong; Lee, Dong-Hun; Lee, Ji-Young; Lee, Eun-Chae; Park, Sang-Won; Lee, Man-Ryul; Oh, Jae-Sang

Hong, Dong-Yong; Lee, Dong-Hun; Lee, Ji-Young; Lee, Eun-Chae; Park, Sang-Won; Lee, Man-Ryul; Oh, Jae-Sang.

Afiliação

Hong DY; Department of Neurosurgery, College of Medicine, Soonchunhyang University, Cheonan Hospital, Cheonan 31151, Korea.
Lee DH; Soonchunhyang Institute of Medi-Bio Science (SIMS), Soon Chun Hyang University, Cheonan 31151, Korea.
Lee JY; Department of Neurosurgery, College of Medicine, Soonchunhyang University, Cheonan Hospital, Cheonan 31151, Korea.
Lee EC; Soonchunhyang Institute of Medi-Bio Science (SIMS), Soon Chun Hyang University, Cheonan 31151, Korea.
Park SW; Department of Neurosurgery, College of Medicine, Soonchunhyang University, Cheonan Hospital, Cheonan 31151, Korea.
Lee MR; Department of Neurosurgery, College of Medicine, Soonchunhyang University, Cheonan Hospital, Cheonan 31151, Korea.
Oh JS; Soonchunhyang Institute of Medi-Bio Science (SIMS), Soon Chun Hyang University, Cheonan 31151, Korea.

Int J Mol Sci ; 23(15)2022 Jul 29.

Article em En | MEDLINE | ID: mdl-35955522

Assuntos

Encefalopatias Metabólicas; Disfunção Cognitiva; Peptídeos beta-Amiloides; Animais; Colesterol/metabolismo; Disfunção Cognitiva/etiologia; Humanos; Lipoproteínas LDL; Camundongos; Camundongos Knockout; Receptores de LDL/metabolismo

Palavras-chave

ER stress; LDLr; SREBP; apoptosis; bloodbrain-barrier (BBB) breakdown; cholesterol metabolism; insulin receptor; lectin-like oxidized LDL receptor-1 (LOX-1); mitochondria; neuroinflammation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encefalopatias Metabólicas / Disfunção Cognitiva Tipo de estudo: Etiology_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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